Restoration of ovarian endocrine function using immunoisolation device

Basic mechanisms of ovarian endocrine function

This review outlines the current understanding of ovarian endocrine development and regulation with both physiological and biochemical background to provide a framework applicable to problems concerning environmental agents and ovarian endocrine function. Two approaches are used. First, the endocrine regulation of follicle development and corpus luteum function is considered in the classical se...

Endocrine control of ovarian function in dogs and other carnivores

Ovarian function in dogs is minimally but successfully evolved and adapted for fertility, and represents a basic model for examining the more complex evolution of ovarian activity in other carnivores and mammals in general. Canids are monoestrous, polytocous, spontaneous ovulators with a spontaneous luteal function producing progesterone for the duration of a normal 2-month pregnancy and unaffe...

Restoration of ovarian function after chemotherapy for osteosarcoma.

AIM To evaluate ovarian function after modern intensive multi-agent chemotherapy for osteosarcoma given during childhood or adolescence. METHODS After discontinuation of treatment, 10 female osteosarcoma survivors were followed up for 1.5-14 (median 4.6) years. Their age at diagnosis was a median of 12.9 (range 6-15) years and at the last follow up 18.6 (range 16-22). The main follow up inclu...

Restoration of ovarian function after allografting of ovarian cortex between genetically non-identical sisters.

BACKGROUND Aggressive chemotherapy generally results in the loss of both endocrine and reproductive functions. For some women, however, oocyte, embryo or ovarian tissue cryopreservation were not proposed at the time. For three such women, orthotopic allotransplantation of fresh ovarian tissue from their genetically non-identical sister was performed. METHODS Three women, aged 20, 15 and 12 ye...

Cell Transplantation and Immunoisolation